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Angus El Primer Guerrero

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El caballero escocés

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\"Pueden atarme a un matrimonio que no quiero, pero aún recuerdo quién soy: Katherine Gray, señora de Hay\". \"Atravesé un mar de tormentas, las llamas ...

  • L'auteur : ,
  • Editeur: HarperCollins Ibérica
  • ISBN: 8413489059
  • Genre: Fiction
  • Nombre de pages: 269
  • Langue: French/English
  • Vues: 396
  • Telecharger: 396
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Détails: "Pueden atarme a un matrimonio que no quiero, pero aún recuerdo quién soy: Katherine Gray, señora de Hay". "Atravesé un mar de tormentas, las llamas del infierno y la muerte. No hay patria, mar o rey que pueda separarme de ti, mi corazón te pertenece". Han pasado dos años y Alistair Murray, un highlander escocés al servicio de la reina inglesa, vuelve de la guerra. Aún le queda una última misión, en apariencia simple, que lo lleva a un perdido castillo inglés disfrazado de monje. Katherine Gray, señora de Hay, es independiente, valiente y obstinada y se niega a que la obliguen a una boda de conveniencia con un noble inglés al que desprecia. Huye de su hogar en busca de libertad, pero ni es tan sencillo ni nada sale como ella pensaba. Un falso monje de intensos ojos azules la ayudará a llegar a las tierras altas de Escocia, donde pretende esconderse. Para la señora de Hay, ahora lo difícil no será escapar de su destino, sino combatir la atracción de cierto guerrero escocés con demasiadas cicatrices y cuya fama de conquistador es conocida en todas las Highlands.


Atlántida: Tierra de Dioses

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Atlántida: «Tierra de Dioses», es una novela fantástica, con temática épica medieval, de género místico, que amalgama teorías científicas, filos ...

  • L'auteur : Leandro Damián Varagnetti
  • Editeur: Chiado Editorial
  • ISBN: 9895187610
  • Genre: Fiction
  • Nombre de pages: 340
  • Langue: French/English
  • Vues: 1984
  • Telecharger: 1984
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Détails: Atlántida: «Tierra de Dioses», es una novela fantástica, con temática épica medieval, de género místico, que amalgama teorías científicas, filosóficas, teológicas y espirituales, acerca del continente perdido y la razón de la existencia del ser humano. El inicio de la civilización, el rediseño de la historia mitológica, la veracidad de las leyendas; como asimismo, la existencia de los avatares angélicos, los híbridos genéticos y los híbridos demoníacos, entre otras cosas, abordan su temática. Por otro lado, establece un paralelismo metafórico entre la realidad y la ficción, promoviendo la generación de conciencia de cada individuo que vive en cohesión social. Cuando la extinción está predeterminada sólo hay un camino por recorrer.


EL HOSPITAL INGLÉS DE GRAÑÉN

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...

  • L'auteur : Julián Jesús Castiella Hernández
  • Editeur: Bubok
  • ISBN: 8468523402
  • Genre: History
  • Nombre de pages: 504
  • Langue: French/English
  • Vues: 1057
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I Am a Warrior Goddess

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She isn’t a princess—she’s a warrior goddess! You don’t have to be a grown-up to be a hero, and I Am a Warrior Goddess shows how in the empowering ...

  • L'auteur : Jennifer Adams
  • Editeur: Sounds True
  • ISBN: 1683640462
  • Genre: Juvenile Fiction
  • Nombre de pages: 32
  • Langue: French/English
  • Vues: 962
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Détails: She isn’t a princess—she’s a warrior goddess! You don’t have to be a grown-up to be a hero, and I Am a Warrior Goddess shows how in the empowering tale of a little girl with big aspirations. Through the clever play between illustration and text, young readers learn how each day is full of opportunities to make a positive impact with ordinary actions. As our heroine connects with the earth, takes care of her body, and finds strength in kindness, she discovers her inner warrior goddess and inspires young girls everywhere to do the same.


Juego de reinas

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Cuando Tautinkom, rey de Erin, cae destronado por Irvyn El Blanco, sus dos hijas se ven obligadas a separarse. Elvia, la montañesa, seguirá a su padre en ...

  • L'auteur : Pablo Núñez
  • Editeur: EDHASA
  • ISBN: 8435046648
  • Genre: Fiction
  • Nombre de pages: 448
  • Langue: French/English
  • Vues: 1588
  • Telecharger: 1588
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Détails: Cuando Tautinkom, rey de Erin, cae destronado por Irvyn El Blanco, sus dos hijas se ven obligadas a separarse. Elvia, la montañesa, seguirá a su padre en el destierro a tierras galaicas. Sin embargo, Wen, conocida como la Dama Blanca, quedará cruelmente cautiva en manos del nuevo rey, a quien jurará venganza eterna. Más allá de la torre de Breoghan, el propio destino y el mar del Norte alejan a quienes nacieron para ser libres, a quienes han de devolverle la libertad a su pueblo. Son tiempos de guerra, de traición, de pasiones..., y las naciones celtas se tambalean. Los caudillos llaman a sus ejércitos a la guerra, mientras que los druidas, aquellos que pueden ver tras las fronteras del futuro, presagian tiempos oscuros. Roble Gris, el más poderoso de ellos, augura lo inevitable. Ambas hermanas han sido predestinadas a encontrarse de nuevo...Y ya nada será lo mismo.


Psicología médica y comunicación

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La información y los conceptos vertidos en esta obra titulada Psicología médica y comunicación son de gran importancia, el lector encontrará la relaci ...

  • L'auteur : Rebeka Jones Guerrero
  • Editeur: Manual Moderno
  • ISBN: 6074488541
  • Genre: Medical
  • Nombre de pages: 441
  • Langue: French/English
  • Vues: 1980
  • Telecharger: 1980
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Détails: La información y los conceptos vertidos en esta obra titulada Psicología médica y comunicación son de gran importancia, el lector encontrará la relación entre mente y cerebro, no siempre fácil de entender, pero indispensable en la comprensión de las funciones mentales. Por ello se han incluido los avances en genética psiquiátrica y el descubrimiento de algunos genes involucrados en las enfermedades mentales. En este punto hay que destacar el desarrollo de la farmacología y la influencia benéfica que esta rama de la medicina ha tenido en el tratamiento o control de las enfermedades psiquiátricas. Por otra parte, hay que destacar que esta obra únicamente contiene aquello de la Psicología médica que es relevante, no solo para el aprendizaje del estudiante, sino que además, es útil en la práctica de los médicos y de los diversos profesionales de la salud, así como de todos aquellos lectores a los que les interese conocerse a sí mismos y ser exitosos en sus relaciones interpersonales. Algunos de los aspectos a destacar son: - La importancia de conocerse a sí mismo - El poder de la personalidad y la influencia que ejerce en el éxito de la relación médico-paciente - Las diversas técnicas de comunicación - El manejo del estrés y la templanza al trabajar en situaciones críticas o imprevistas - El saber observar las reacciones y aprender el manejo de las emociones - El manejo de la sexualidad en la relación médico-paciente - El desarrollo de la vocación de servicio y el apoyo a quien lo necesite - La comprensión de la diferencia entre enfermedad y padecimiento - El desarrollo de las aptitudes y actitudes humanas para ser el médico humanista que la sociedad pide y necesita Psicología médica y comunicación suministra las herramientas para lograrlo.


Science and Empires

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SCIENCE AND EMPIRES: FROM THE INTERNATIONAL COLLOQUIUM TO THE BOOK Patrick PETITJEAN, Catherine JAMI and Anne Marie MOULIN The International Colloquium "Sc ...

  • L'auteur : P. Petitjean,Cathérine Jami,A.M. Moulin
  • Editeur: Springer Science & Business Media
  • ISBN: 9401125945
  • Genre: Science
  • Nombre de pages: 418
  • Langue: French/English
  • Vues: 513
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Détails: SCIENCE AND EMPIRES: FROM THE INTERNATIONAL COLLOQUIUM TO THE BOOK Patrick PETITJEAN, Catherine JAMI and Anne Marie MOULIN The International Colloquium "Science and Empires - Historical Studies about Scientific De velopment and European Expansion" is the product of an International Colloquium, "Sciences and Empires - A Comparative History of Scien tific Exchanges: European Expansion and Scientific Development in Asian, African, American and Oceanian Countries". Organized by the REHSEIS group (Research on Epistemology and History of Exact Sciences and Scientific Institutions) of CNRS (National Center for Scientific Research), the colloquium was held from 3 to 6 April 1990 in the UNESCO building in Paris. This colloquium was an idea of Professor Roshdi Rashed who initiated this field of studies in France some years ago, and proposed "Sciences and Empires" as one of the main research programmes for the The project to organize such a colloquium was a bit REHSEIS group. of a gamble. Its subject, reflected in the title "Sciences and Empires", is not a currently-accepted sub-discipline of the history of science; rather, it refers to a set of questions which found autonomy only recently. The terminology was strongly debated by the participants and, as is frequently suggested in this book, awaits fuller clarification.


Worlds Enough & Time

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An extraordinary artist with few rivals in his chosen arena, Dan Simmons possesses a restless talent that continually presses boundaries while tantalizing ...

  • L'auteur : Dan Simmons
  • Editeur: Harper Collins
  • ISBN: 0061809438
  • Genre: Fiction
  • Nombre de pages: 272
  • Langue: French/English
  • Vues: 524
  • Telecharger: 524
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Détails: An extraordinary artist with few rivals in his chosen arena, Dan Simmons possesses a restless talent that continually presses boundaries while tantalizing the mind and touching the soul. Now he offers us a superb quintet of novellas -- five dazzling masterworks of speculative fiction, including "Orphans of the Helix," his award-winning return to the Hyperion Universe -- that demonstrates the unique mastery, breathtaking invention, and flawless craftsmanship of one of contemporary fiction's true greats. Human colonists seeking something other than godhood encounter their long-lost "cousins"...and an ancient scourge. A devastated man in suicide's embrace is caught up in a bizarre cat-and-mouse game with a young woman possessing a world-ending power. The distant descendants of a once-oppressed people learn a chilling lesson about the persistence of the past. A terrifying ascent up the frigid, snow-swept slopes of K2 shatters preconceptions and reveals the true natures of four climbers, one of whom is not human. At the intersection of a grand past and a threadbare present, an aging American in Russia confronts his own mortality as he glimpses a wondrous future.


Claimed by the Highlander

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With his tawny mane, battle-hewn brawn, and ferocious roar, Angus "The Lion" MacDonald is the most fearsome warrior Lady Gwendolen has ever seen—and she ...

  • L'auteur : Julianne MacLean
  • Editeur: St. Martin\'s Paperbacks
  • ISBN: 1429965320
  • Genre: Fiction
  • Nombre de pages: 336
  • Langue: French/English
  • Vues: 1514
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Détails: With his tawny mane, battle-hewn brawn, and ferocious roar, Angus "The Lion" MacDonald is the most fearsome warrior Lady Gwendolen has ever seen—and she is his most glorious conquest. Captured in a surprise attack on her father's castle, Gwendolen is now forced to share her bed with the man who defeated her clan. But, in spite of Angus's overpowering charms, she refuses to surrender her innocence without a fight... With her stunning beauty, bold defiance, and brazen smile, Gwendolen is the most infuriating woman Angus has ever known—and the most intoxicating. Forcing her to become his bride will unite their two clans. But conquering Gwendolen's heart will take all his skills as a lover. Night after night, his touch sets her on fire. Kiss after kiss, his hunger fuels her passion. But, as Gwendolen's body betrays her growing love for Angus, a secret enemy plots to betray them both... Julianne MacLean delivers a compelling, ravishing historical romance in Claimed by the Highlander.


All Is Silence

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Manuel Rivas delivers a literary masterpiece about three young friends growing up in a community which is bound by a conspiracy of silence Fins and Brinco ...

  • L'auteur : Manuel Rivas
  • Editeur: Random House
  • ISBN: 1448156009
  • Genre: Fiction
  • Nombre de pages: 256
  • Langue: French/English
  • Vues: 679
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Détails: Manuel Rivas delivers a literary masterpiece about three young friends growing up in a community which is bound by a conspiracy of silence Fins and Brinco are best friends, and they both adore the wild and beautiful Leda. The three young friends spend their days exploring the dunes and picking through the treasures that the sea washes on to the shores of Galicia. One day, as they are playing in the abandoned school on the edge of the village, they come across treasure of another kind: a huge cache of whisky hidden under a sheet. But before they can exploit their discovery a shot rings out, and a man wearing an impeccable white suit and panama hat enters the room. That day they learn the most important lesson of all, that the mouth is for keeping quiet.


PISA Under Examination

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From the 23rd to 26th of November 2009 in La Palma island, in the Canaries, the Comparative Education Society in Europe (CESE) organized an international s ...

  • L'auteur : Miguel A. Pereyra,Hans-Georg Kotthoff,Robert Cowen
  • Editeur: Springer Science & Business Media
  • ISBN: 9460917402
  • Genre: Education
  • Nombre de pages: 334
  • Langue: French/English
  • Vues: 1598
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Détails: From the 23rd to 26th of November 2009 in La Palma island, in the Canaries, the Comparative Education Society in Europe (CESE) organized an international symposium entitled PISA under Examination: Changing Knowledge, Changing Tests, and Changing Schools. During four days seventeen leading scholars of Europe and America presented their contributions to debate the different problematiques of the remarkable phenomenon represented by the OECD Programme for International Student Assessment or PISA. PISA is not merely an educational event. It is also a media circus which involves the public rehearsal for reasons for failure or success; and even, in some cases, public and political and academic explanations about why 'failure' was not really that, and why 'success' was not really that either. At the centre of all these indications, we find the growing influence of international agencies on education and schooling which is decisively contributing to a marketisation of the field of education, in the context of an increasingly multilevel and fragmented arena for educational governance based on the formulation, the regulation and the transnational coordination and convergence of policies, buttressed at the same time by the diffusion of persuasive discursive practice. Organized in four sections entitled The Comparative Challenges of the OCDE PISA Programme, PISA and School Knowledge, The Assessment of PISA, School Effectiveness and the Socio-cultural Dimension, PISA and the Immigrant Student Question, and Extreme Visions of PISA: Germany and Finland, the contributions of this book offers a comprehensive approach of all these challenging and significant issues written from different and distinct research and academic traditions.


Trends and Applications in Software Engineering

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This book includes a selection of papers from the 2017 International Conference on Software Process Improvement (CIMPS’17), presenting trends and applica ...

  • L'auteur : Jezreel Mejia,Mirna Muñoz,Álvaro Rocha,Yadira Quiñonez,Jose Calvo-Manzano
  • Editeur: Springer
  • ISBN: 3319693417
  • Genre: Computers
  • Nombre de pages: 306
  • Langue: French/English
  • Vues: 1823
  • Telecharger: 1823
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Détails: This book includes a selection of papers from the 2017 International Conference on Software Process Improvement (CIMPS’17), presenting trends and applications in software engineering. Held from 18th to 20th October 2017 in Zacatecas, Mexico, the conference provided a global forum for researchers and practitioners to present and discuss the latest innovations, trends, results, experiences and concerns in various areas of software engineering, including but not limited to software processes, security in information and communication technology, and big data. The main topics covered are organizational models, standards and methodologies, software process improvement, knowledge management, software systems, applications and tools, information and communication technologies and processes in non-software domains (mining, automotive, aerospace, business, health care, manufacturing, etc.) with a demonstrated relationship to software engineering challenges.


The Right Way to Teach Chess to Kids

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This accessible how-to guide for parents and teachers on the best way to teach chess to children, from international chess expert Richard James, is linked ...

  • L'auteur : Richard James
  • Editeur: Robinson
  • ISBN: 0716023407
  • Genre: Games & Activities
  • Nombre de pages: 224
  • Langue: French/English
  • Vues: 1957
  • Telecharger: 1957
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Détails: This accessible how-to guide for parents and teachers on the best way to teach chess to children, from international chess expert Richard James, is linked to both his bestselling book, Chess for Kids, and his website chessKIDS academy. James, who taught grandmasters Luke McShane and Jonathan Rowson, shows how learning chess is interesting and fun. It can also help children develop life skills, such as decision-making and social skills, and be a springboard to other subjects in the school curriculum, such as maths, science, history and even languages. In an easy-to-follow, fun way, James explains how to structure short lessons with worksheets and other activities to introduce the chess pieces, chess notation and chess-board dynamics - so that children can understand the thinking behind the moves and start playing and enjoying this fascinating game.


The SAGE Handbook of Human Trafficking and Modern Day Slavery

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Millions of people around the world are forced to work without pay and under threat of violence. These individuals can be found working in brothels, factor ...

  • L'auteur : Jennifer Bryson Clark,Sasha Poucki
  • Editeur: SAGE
  • ISBN: 1526450445
  • Genre: Political Science
  • Nombre de pages: 584
  • Langue: French/English
  • Vues: 1899
  • Telecharger: 1899
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Détails: Millions of people around the world are forced to work without pay and under threat of violence. These individuals can be found working in brothels, factories, mines, farm field, restaurants, construction sites and private homes: many have been tricked by human traffickers and lured by false promises of good jobs or education, some are forced to work at gunpoint, while others are trapped by phony debts from unscrupulous moneylenders. The SAGE Handbook of Human Trafficking and Modern-Day Slavery provides a comprehensive, interdisciplinary and global look at the diverse issues surrounding human trafficking and slavery in the post-1945 environment. Covering everything from history, literature and politics to economics, international law and geography, this Handbook is essential reading for academics and researchers, as well as for policy-makers and non-governmental organisations


Beneficial Microbes in Agro-Ecology

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Beneficial Microbes in Agro-Ecology: Bacteria and Fungi is a complete resource on the agriculturally important beneficial microflora used in agricultural p ...

  • L'auteur : N. Amaresan,M. Senthil Kumar,K. Annapurna,Krishna Kumar,A. Sankaranarayanan
  • Editeur: Academic Press
  • ISBN: 0128235586
  • Genre: Business & Economics
  • Nombre de pages: 932
  • Langue: French/English
  • Vues: 1516
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Détails: Beneficial Microbes in Agro-Ecology: Bacteria and Fungi is a complete resource on the agriculturally important beneficial microflora used in agricultural production technologies. Included are 30 different bacterial genera relevant in the sustainability, mechanisms, and beneficial natural processes that enhance soil fertility and plant growth. The second part of the book discusses 23 fungal genera used in agriculture for the management of plant diseases and plant growth promotion. Covering a wide range of bacteria and fungi on biocontrol and plant growth promoting properties, the book will help researchers, academics and advanced students in agro-ecology, plant microbiology, pathology, entomology, and nematology. Presents a comprehensive collection of agriculturally important bacteria and fungi Provides foundational knowledge of each core organism utilized in agro-ecology Identifies the genera of agriculturally important microorganisms


Inclusions in Prokaryotes

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The new series "Microbiology Monographs" begins with two volumes on intracellular components in prokaryotes. In this first volume, "Inclusions in Prokaryot ...

  • L'auteur : Jessup M. Shively
  • Editeur: Springer Science & Business Media
  • ISBN: 3540337741
  • Genre: Science
  • Nombre de pages: 349
  • Langue: French/English
  • Vues: 750
  • Telecharger: 750
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Détails: The new series "Microbiology Monographs" begins with two volumes on intracellular components in prokaryotes. In this first volume, "Inclusions in Prokaryotes", the components, labeled inclusions, are defined as discrete bodies resulting from synthesis of a metabolic product. Research on the biosynthesis and reutilization of the accumulated materials is still in progress, and interest in the inclusions is growing. This comprehensive volume provides historical background and comprehensive reviews of eight well-known prokaryotic inclusions.


The Climate Crisis

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Essays that address the question: how can people and class agency change this destructive course of history? Capitalism’s addiction to fossil fuels is he ...

  • L'auteur : Vishwas Satgar
  • Editeur: NYU Press
  • ISBN: 177614208X
  • Genre: Political Science
  • Nombre de pages: 372
  • Langue: French/English
  • Vues: 1880
  • Telecharger: 1880
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Détails: Essays that address the question: how can people and class agency change this destructive course of history? Capitalism’s addiction to fossil fuels is heating our planet at a pace and scale never before experienced. Extreme weather patterns, rising sea levels and accelerating feedback loops are a commonplace feature of our lives. The number of environmental refugees is increasing and several island states and low-lying countries are becoming vulnerable. Corporate-induced climate change has set us on an ecocidal path of species extinction. Governments and their international platforms such as the Paris Climate Agreement deliver too little, too late. Most states, including South Africa, continue on their carbon-intensive energy paths, with devastating results. Political leaders across the world are failing to provide systemic solutions to the climate crisis. This is the context in which we must ask ourselves: how can people and class agency change this destructive course of history? Volume three in the Democratic Marxism series, The Climate Crisis investigates eco-socialist alternatives that are emerging. It presents the thinking of leading climate justice activists, campaigners and social movements advancing systemic alternatives and developing bottom-up, just transitions to sustain life. Through a combination of theoretical and empirical work, the authors collectively examine the challenges and opportunities inherent in the current moment. This volume builds on the class-struggle focus of Volume 2 by placing ecological issues at the centre of democratic Marxism. Most importantly, it explores ways to renew historical socialism with democratic, eco-socialist alternatives to meet current challenges in South Africa and the world.


Handbook of Poultry Science and Technology, Primary Processing

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A comprehensive reference for the poultry industry—Volume 1 describes everything from husbandry up to preservation With an unparalleled level of coverage ...

  • L'auteur : Isabel Guerrero-Legarreta
  • Editeur: John Wiley & Sons
  • ISBN: 9780470504444
  • Genre: Technology & Engineering
  • Nombre de pages: 804
  • Langue: French/English
  • Vues: 1136
  • Telecharger: 1136
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Détails: A comprehensive reference for the poultry industry—Volume 1 describes everything from husbandry up to preservation With an unparalleled level of coverage, the Handbook of Poultry Science and Technology provides an up-to-date and comprehensive reference on poultry processing. Volume 1 describes husbandry, slaughter, preservation, and safety. It presents all the details professionals need to know beginning with live poultry through to the freezing of whole poultry and predetermined cut parts. Throughout, the coverage focuses on one paramount objective: an acceptable quality and a safe product for consumer purchase and use. The text includes safety requirements and regulatory enforcement in the United States, EU, and Asia. Volume 1: Primary Processing is divided into seven parts: Poultry: biology to pre-mortem status—includes such topics as classification and biology, competitive exclusion, transportation to the slaughterhouse, and more Slaughtering and cutting—includes the slaughterhouse building and required facilities, equipment, and operations; carcass evaluation and cutting; kosher and halal slaughter; and more Preservation: refrigeration and freezing—includes the biology and physicochemistry of poultry meat in rigor mortis under ambient temperature, as well as changes that occur during freezing and thawing; engineering principles; equipment and processes; quality; refrigeration and freezing for various facilities; and more Preservation: heating, drying, chemicals, and irradiation Composition, chemistry, and sensory attributes—includes quality characteristics, microbiology, nutritional components, chemical composition, and texture of raw poultry meat Eggs—includes egg attributes, science, and technology Sanitation and Safety—includes PSE, poultry-related foodborne diseases, OSHA requirements, HACCP and its application, and more


Finance for Development

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Access to finance is critical in setting the course for development in emerging market economies. In this innovative study, which provides the first book-l ...

  • L'auteur : Barbara Stallings
  • Editeur: Brookings Institution Press
  • ISBN: 9780815797913
  • Genre: Business & Economics
  • Nombre de pages: 316
  • Langue: French/English
  • Vues: 1840
  • Telecharger: 1840
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Détails: Access to finance is critical in setting the course for development in emerging market economies. In this innovative study, which provides the first book-length analysis of the Latin American financial sector, Barbara Stallings and Rogerio Studart examine the dramatic changes resulting from financial liberalization in the region. The authors begin by discussing the critical transformations taking place in Latin America since 1990—a period marked by acceleration toward a new open, market-oriented development model, and away from a semi-closed model relying heavily on the state. Stallings and Studart examine changes in ownership of the financial sector and government regulation of banking, evaluate the role of capital markets as a source of finance, and compare Latin America's financial sector to that of East Asia. The second section of the book features case studies that demonstrate the changes occurring in Chile, Mexico, and Brazil with particular reference to finance for investment and access to credit. The authors conclude with a set of policy recommendations aimed at strengthening Latin American banks and capital markets so that they can play a greater role in supporting economic development.


A Pharmacology Primer

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A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the appli ...

  • L'auteur : Terry Kenakin
  • Editeur: Academic Press
  • ISBN: 0128139587
  • Genre: Medical
  • Nombre de pages: 488
  • Langue: French/English
  • Vues: 569
  • Telecharger: 569
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Détails: A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data